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Diabetes Notes

Gene Mutation Thought To Control Energy Levels In Cells Promising For Diabetics

by Kendra James, RN on September 21st, 2007

cells-ampk.jpgResearchers out of University of Ottawa have discovered a mutation in a gene that is considered to be a major controller in the way that energy levels are used in our bodies. This is a big discovery for endurance athletes as well as diabetics.

What gene is being examined and how does this pertain specifically to diabetics? The gene adenosine monophosphate-activated protein kinase, AMPK, which controls the amount of energy in our cells by becoming active when fuel stores start to deplete such as in extreme exercise. The mutation showed a doubling of the energy use in the cells. In diabetics there are high levels of fat stored in the muscle have been linked to insulin resistance, so increased energy production would be a leg up in the right direction.

In addition, as metformin, a drug commonly used to both prevent and treat diabetes, acts by increasing AMPK activity, this discovery provides valuable information for pharmaceutical research.

Could a new drug come out of this discovery? Who knows at this point but it is promising indeed.

via Science Daily

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POSTED IN: Diabetes Management, Research

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