Diabetes Notes

Pro3(GIP) To Promote Weight Loss, Improve Insulin Resistance And Reverse Diabetes

by Kendra James, RN on January 7th, 2008

Here’s to promoting weight loss, improving insulin resistance and reversing diabetes? A chemical identified as Pro3(GIP), gastric inhibitory polypeptide receptor blockade was found to accomplish the before mentioned… in animals.

GIP is a hormone that is secreted in response to your food intake . It inhibits the secretion of acids that stimulate the release of insulin as part of the digestive process thus Pro3(GIP) combating this.

While the significance of its action is largely unknown, its potent and prolonged stimulation after a high-fat diet has led researchers to speculate it may play a key role in metabolizing fat. Research has shown that high fat feeding results in elevated circulating GIP concentrations, traits often found in patients who are obese with diabetes. GIP also effects the growth of fat cells. Other studies have shown that mice injected with the GIP receptor antagonist - (Pro3)GIP - can reverse or prevent many of the metabolic abnormalities associated with obesity.

So, in a nutshell… more GIP bad, less GIP good! That was easy, haha. And just what did they find with this particular study?

This study showed that blocking GIP activity using (Pro3)GIP in mice with established, high fat diet-induced obesity and diabetes results in significant weight loss, improvement of insulin resistance and amelioration of diabetes.

Researchers are now examining the findings as an interesting new way to battle obesity and metabolic disorders.

Share This

Related Stories

Weight loss most effective treatment for type 2 diabetes
Type 2 Diabetics better off after Gastric Bypass
Gastric Banding Surgery Puts A Hold On Type 2 Diabetes
Eating at regular intervals essential to good health and less diabetes
Fluffy gets the beedies

POSTED IN: Research, Uncategorized